Services

Early Evidence Strategy

Building evidence strategies for new healthcare technologies that align with JCA and HTA expectations from the outset.

  • HTA readiness through guideline reviews, scientific advice preparation, and JCA PICO simulations ahead of pivotal trial design.
  • Early competitive landscape assessment to support development of a data-driven target product profile (TPP). Using evidence synthesis and indirect treatment comparison methods, we generate comparative insights to inform study design and strengthen product positioning.
  • Evidence gap analyses to reduce uncertainty and align value claims with HTA expectations and market access strategy. 
  • Advisory boards to gather expert insights and inform evidence generation strategy across key markets. We recruit balanced boards, facilitate focused discussions, and support alignment between stakeholders.
Other services include:
Policy and methods
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
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Neurology & mental health
Evaluating the cost-effectiveness of a medical device
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Respiratory
Modelling survival after the clinical trials have ended
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Oncology
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
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Rare diseases
Gaining reimbursement for a drug targeting a rare disease
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Cardiometabolic health
Evaluating the cost-effectiveness of a diagnostic device
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Dermatology
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
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Dermatology
Validating comparisons of disease treatments in the absence of head-to-head trials
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“The team went above and beyond our expectations for our project. We were grateful that Symmetron was able to meet our deadlines, and to deliver a very large volume of work”
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Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Evaluating the cost-effectiveness of a medical device
Evaluating the cost-effectiveness of a medical device
Modelling survival after the clinical trials have ended
Modelling survival after the clinical trials have ended
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Gaining reimbursement for a drug targeting a rare disease
Gaining reimbursement for a drug targeting a rare disease
Evaluating the cost-effectiveness of a diagnostic device
Evaluating the cost-effectiveness of a diagnostic device
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Validating comparisons of disease treatments in the absence of head-to-head trials
Validating comparisons of disease treatments in the absence of head-to-head trials