Services

Real World Evidence (RWE)

Generating decision-ready real-world evidence to support HTA, regulatory, reimbursement, and evidence-generation decisions across global and local settings.

  • Data source identification and feasibility assessment, including registries, claims databases, electronic health records, and federated data networks.
  • Robust RWE study design, from research question refinement to protocol development and statistical analysis planning.
  • Real-world evidence analysis and interpretation, using federated or direct data access routes to address evidence gaps across clinical outcomes, safety, care pathways, resource use, and economic model inputs, with findings translated into decision-ready insights.
Other services include:
  • Editorial support
  • Advisory board material development
Policy and methods
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Author
Date
Dermatology
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Author
Date
Oncology
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Author
Date
Respiratory
Modelling survival after the clinical trials have ended
Author
Date
Rare diseases
Gaining reimbursement for a drug targeting a rare disease
Author
Date
Neurology & mental health
Evaluating the cost-effectiveness of a medical device
Author
Date
Dermatology
Validating comparisons of disease treatments in the absence of head-to-head trials
Author
Date
Cardiometabolic health
Evaluating the cost-effectiveness of a diagnostic device
Author
Date

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“The team went above and beyond our expectations for our project. We were grateful that Symmetron was able to meet our deadlines, and to deliver a very large volume of work”
“One of the most efficient partnerships I’ve had with an external group.”
“Symmetron has expertise in all areas, including project management, SLRs, NMAs, economic modelling and a good relationship with the medical writer.”
“Our expectations were met, and the project was handled at the highest level."
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Modelling survival after the clinical trials have ended
Modelling survival after the clinical trials have ended
Gaining reimbursement for a drug targeting a rare disease
Gaining reimbursement for a drug targeting a rare disease
Evaluating the cost-effectiveness of a medical device
Evaluating the cost-effectiveness of a medical device
Validating comparisons of disease treatments in the absence of head-to-head trials
Validating comparisons of disease treatments in the absence of head-to-head trials
Evaluating the cost-effectiveness of a diagnostic device
Evaluating the cost-effectiveness of a diagnostic device