Services

Joint Clinical Assessment

Supporting JCA readiness through proactive evidence planning and coordinated submission preparation.

  • Joint Scientific Consultation support to inform evidence strategy and pivotal trial design, ensuring alignment with JCA and EU HTA expectations.  
  • Early PICO scoping, simulation, and validation to anticipate JCA requirements, and reduce evidence gaps. 
  • Development of robust JCA dossiers, through proactive preparation and targeted updates following PICO confirmation, supporting submission readiness within required timelines. 
Other services include:
  • Missing data imputation
  • Propensity score matching
  • Statistical testing
Dermatology
Validating comparisons of disease treatments in the absence of head-to-head trials
Author
Date
Neurology & mental health
Evaluating the cost-effectiveness of a medical device
Author
Date
Rare diseases
Gaining reimbursement for a drug targeting a rare disease
Author
Date
Cardiometabolic health
Evaluating the cost-effectiveness of a diagnostic device
Author
Date
Policy and methods
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Author
Date
Respiratory
Modelling survival after the clinical trials have ended
Author
Date
Oncology
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Author
Date
Dermatology
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Author
Date

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“The team went above and beyond our expectations for our project. We were grateful that Symmetron was able to meet our deadlines, and to deliver a very large volume of work”
“One of the most efficient partnerships I’ve had with an external group.”
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“Our expectations were met, and the project was handled at the highest level."
Validating comparisons of disease treatments in the absence of head-to-head trials
Validating comparisons of disease treatments in the absence of head-to-head trials
Evaluating the cost-effectiveness of a medical device
Evaluating the cost-effectiveness of a medical device
Gaining reimbursement for a drug targeting a rare disease
Gaining reimbursement for a drug targeting a rare disease
Evaluating the cost-effectiveness of a diagnostic device
Evaluating the cost-effectiveness of a diagnostic device
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Developing a framework for analysing the impact of patient-centred outcomes for achieving reimbursement in the UK
Modelling survival after the clinical trials have ended
Modelling survival after the clinical trials have ended
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Overcoming limited evidence to gain reimbursement for a blockbuster oncology drug
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments
Overcoming the short-term bias in clinical evidence to compare long-term efficacy of psoriasis treatments