Health economic (HE) decision-analytic models are a critical component of health technology assessments (HTAs), and evaluation of model validity can support a decision-maker’s ability to trust model results. While most models undergo some level of validation, recommendations around how, when, and by whom it should be conducted vary widely. At Symmetron, we ensure every model goes through rigorous scrutiny, giving clients confidence in the results.

Why model validation matters

A model that has not been validated carries many risks, whether it is an advanced-stage model used to support a HTA submission, or an early economic model designed to explore the cost-effectiveness drivers of a treatment and support strategic planning. It can derail future trial design, pricing strategies and reimbursement if the model does not accurately reflect the disease, the evidence or clinical practice. So, how do you know if your model will stand up to scrutiny from HTA regulatory bodies or internal stakeholders? This is where Symmetron can help.

Validations throughout the different stages of model development

Comprehensive model validation is not a one-off task; it is a continuous process that varies according to the type of validation. It is a team effort involving model developers, clinical experts and independent reviewers at different stages. Whilst model validation is typically part of our core project deliverables at Symmetron, we also have an extensive network of external experts who we can involve to independently review and validate model inputs, assumptions and results as needed. This approach ensures the model is not only technically sound, but also clinically accurate and easily understood by someone with little knowledge of the model.

Explore our approach in detail

We invite you to explore our ISPOR EU 2024 poster, which presents a targeted literature review on model validation in HE decision-analytic models, emphasising the roles, processes, and key steps involved across all stages of model development to enhance credibility.

View our ISPOR poster on Model Validation (PDF)

Why should clients trust Symmetron for validation

• Years of expertise: Our team includes modellers that have had years of experience on HTA submissions, peer-reviewed health economic publications and have worked within a wide range of therapeutic areas. Whatever the model or disease area, we have the expertise to deliver rigorous, reliable validation results.
• Proactive checks: We don’t wait until the final draft to validate and check, we do it early and often to ensure we have no blind spots.
• Transparent reporting: Our clients receive clear reports and details during every step of model development and validation at Symmetron.
• Decision-maker confidence: We ensure the model addresses the needs of the client and is fit for the purpose it was built for; each model is uniquely built and tailored to the nuances of the disease area and treatment landscape. This ensures confidence in the decisions informing models that have been validated by Symmetron.

Ready to ensure your model stands up to scrutiny?

Contact Symmetron today to learn how our team’s validation expertise can help you build trust, reduce risk, and achieve treatment success with your economic model.